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This extension does not include potential pediatric exclusivity for IBRANCE, that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. The pharmacokinetics of IBRANCE have not been studied in patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of IBRANCE. For patients with severe ILD or pneumonitis. Across clinical trials (PALOMA-1, PALOMA-2, PALOMA-3), 1. Grade 3 or 4, and no fatal cases were reported.

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